開發項目

相關研究成果

AD related references

  1. Lee C-C, Chang C-P, Lin C-J, Lai H-L, Kao Y-H, Cheng S-J, Chen H-M, Liao Y-P, Faivre E, Buée L, Blum D, Fang J-M, Chern Y (2018) Adenosine augmentation evoked by an ENT1 inhibitor improves memory impairment and neuronal plasticity in the APP/PS1 mouse model of Alzheimer’s disease. Molecular Neurobiology, 55, 8936-8952.
  2. Chang C-P, Chang Y-G, Nguyen TNA, Cheng S-J, Chen H-M, Jin L-W, Buee L, Blum D, Liao Y-F, Lin C-J, Chern Y (2021) Equilibrative nucleoside transporter 1 inhibition rescues energy dysfunction and pathology in a model of tauopathy. Acta Neuropathol Commun, 9, 112-129.

HD related references

  1. Huang, NK, JH Lin, JT Lin, CI Lin, EM Liu, CJ Lin, WP Chen, YC Shen, HM Chen, JB Chen, HL Lai, CW Yang, MC Chiang, YS Wu, C Chang, JF Chen, JM Fang, YL Lin, Y Chern (2011) A new drug design targeting the adenosinergic system for Huntington’s disease. PLoS One, 6, e20934.
  2. 2. Kao Y-H, Lin M-S, Chen C-M, Wu Y-R, Chen H-M, Lai H-L, Chern Y, and Lin C-J (2017) Targeting ENT1 and adenosine tone for the treatment of Huntington’s disease. Human Molecular Genetics, 26, 467-478.

ALS related references

  1. Liu Y-J, Ju T-C, Chen H-M, Jang Y-S, Lee L-M, Lai H-L, Tai H-C, Fang J-M, Lin Y-L, Tu P-H, Chern Y (2015) Activation of AMP-activated protein kinase α1 mediates mislocalization of TDP-43 in amyotrophic lateral sclerosis. Human Molecular Genetics, 24, 787-801.
  2. Liu Y-J, Lee L-M, Lai H-L, Chern Y (2015) Aberrant activation of AMP-activated protein kinase contributes to the abnormal distribution of HuR in amyotrophic lateral sclerosis. FEBS Letters, 589, 432-439.
  3. Lai C-Y, Liu Y-J, Lai H-L, Chen H-M, Kuo H-C, Liao Y-P, Chern Y (2018) The D2 dopamine receptor interferes with the protective effect of the A2A adenosine receptor on TDP-43 mislocalization in experimental models of motor neuron degeneration. Frontiers in Neuroscience, 12, 187.